Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-28 | West Georgia (221) | 34 | Samford (198) | 3 | Final | L | -31 |
| 2 | 2025-09-06 | The Citadel (216) | 40 | Samford (198) | 13 | Final | L | -27 |
| 3 | 2025-09-13 | Samford (198) | 7 | Baylor (38) | 42 | Final | L | -35 |
| 4 | 2025-09-20 | Samford (261) | 35 | Western Carolina (224) | 50 | Final | L | -15 |
| 5 | 2025-09-27 | Furman (164) | 31 | Samford (260) | 13 | Final | L | -18 |
| 6 | 2025-10-04 | Samford (258) | 21 | Mercer (152) | 45 | Final | L | -24 |
| 7 | 2025-10-18 | Samford (247) | 24 | Virginia Military (260) | 22 | Final | W | 2 |
| 8 | 2025-10-25 | Chattanooga (191) | 49 | Samford (255) | 13 | Final | L | -36 |
| 9 | 2025-11-01 | Samford (256) | 16 | Wofford (221) | 26 | Final | L | -10 |
| 10 | 2025-11-08 | East Tennessee State (201) | 38 | Samford (257) | 14 | Final | L | -24 |
| 11 | 2025-11-15 | Samford (255) | 16 | Austin Peay (162) | 30 | Final | L | -14 |
| 12 | 2025-11-22 | Samford (255) | 0 | Texas A&M (3) | 48 | Final | L | -48 |