Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Murray State (251) | 17 | East Tennessee State (170) | 45 | Final | W | 28 |
| 2 | 2025-09-06 | East Tennessee State (170) | 17 | Tennessee (9) | 72 | Final | L | -55 |
| 3 | 2025-09-13 | East Tennessee State (170) | 31 | West Georgia (221) | 35 | Final | L | -4 |
| 4 | 2025-09-20 | Elon (188) | 16 | East Tennessee State (165) | 26 | Final | W | 10 |
| 5 | 2025-09-27 | Mercer (153) | 38 | East Tennessee State (186) | 34 | Final | L | -4 |
| 6 | 2025-10-04 | East Tennessee State (191) | 22 | Furman (153) | 31 | Final | L | -9 |
| 7 | 2025-10-11 | Virginia Military (252) | 10 | East Tennessee State (188) | 45 | Final | W | 35 |
| 8 | 2025-10-18 | East Tennessee State (207) | 38 | Chattanooga (197) | 42 | Final | L | -4 |
| 9 | 2025-10-25 | Wofford (227) | 10 | East Tennessee State (200) | 14 | Final | W | 4 |
| 10 | 2025-11-08 | East Tennessee State (201) | 38 | Samford (257) | 14 | Final | W | 24 |
| 11 | 2025-11-15 | East Tennessee State (183) | 52 | Western Carolina (181) | 35 | Final | W | 17 |
| 12 | 2025-11-22 | The Citadel (234) | 26 | East Tennessee State (182) | 28 | Final | W | 2 |