Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2026-09-06 | Louisville (35) | 38 | Ole Miss (7) | 41 | Final | L | -3 |
| 2 | 2026-09-11 | Villanova (132) | 13 | Louisville (35) | 59 | Final | W | 46 |
| 3 | 2026-09-19 | SMU | 0 | Louisville | 0 | Scheduled - 3:30 PM | - | - |
| 4 | 2026-09-26 | Wake Forest | 0 | Louisville | 0 | Scheduled - 12:00 PM | - | - |
| 5 | 2026-10-03 | Louisville | 0 | North Carolina State | 0 | Scheduled - TBD | - | - |
| 6 | 2026-10-09 | Florida State | 0 | Louisville | 0 | Scheduled - 7:00 PM | - | - |
| 7 | 2026-10-17 | Louisville | 0 | Syracuse | 0 | Scheduled - TBD | - | - |
| 8 | 2026-10-31 | Stanford | 0 | Louisville | 0 | Scheduled - TBD | - | - |
| 9 | 2026-11-07 | Louisville | 0 | Georgia Tech | 0 | Scheduled - TBD | - | - |
| 10 | 2026-11-14 | Louisville | 0 | North Carolina | 0 | Scheduled - TBD | - | - |
| 11 | 2026-11-21 | Pittsburgh | 0 | Louisville | 0 | Scheduled - TBD | - | - |
| 12 | 2026-11-28 | Louisville | 0 | Kentucky | 0 | Scheduled - TBD | - | - |