Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Charleston Southern (250) | 3 | Vanderbilt (40) | 45 | Final | W | 42 |
| 2 | 2025-09-06 | Vanderbilt (40) | 44 | Virginia Tech (45) | 20 | Final | W | 24 |
| 3 | 2025-09-13 | Vanderbilt (40) | 31 | South Carolina (13) | 7 | Final | W | 24 |
| 4 | 2025-09-20 | Georgia State (114) | 21 | Vanderbilt (14) | 70 | Final | W | 49 |
| 5 | 2025-09-27 | Utah State (61) | 35 | Vanderbilt (5) | 55 | Final | W | 20 |
| 6 | 2025-10-04 | Vanderbilt (21) | 14 | Alabama (8) | 30 | Final | L | -16 |
| 7 | 2025-10-18 | LSU (28) | 24 | Vanderbilt (15) | 31 | Final | W | 7 |
| 8 | 2025-10-25 | Missouri (28) | 10 | Vanderbilt (13) | 17 | Final | W | 7 |
| 9 | 2025-11-01 | Vanderbilt (18) | 31 | Texas (16) | 34 | Final | L | -3 |
| 10 | 2025-11-08 | Auburn (56) | 38 | Vanderbilt (15) | 45 | Final/OT | W | 7 |
| 11 | 2025-11-22 | Kentucky (56) | 17 | Vanderbilt (14) | 45 | Final | W | 28 |
| 12 | 2025-11-29 | Vanderbilt (14) | 45 | Tennessee (28) | 24 | Final | W | 21 |
| 13 | 2025-12-31 | Iowa (21) | 34 | Vanderbilt (14) | 27 | Final | L | -7 |