Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Thomas More | 3 | Southern Illinois (184) | 49 | Final | W | 46 |
| 2 | 2025-09-06 | Southern Illinois (184) | 17 | Purdue (133) | 34 | Final | L | -17 |
| 3 | 2025-09-13 | Southern Illinois (184) | 37 | Tennessee-Martin (137) | 10 | Final | W | 27 |
| 4 | 2025-09-20 | Southern Illinois (152) | 59 | Southeast Missouri State (206) | 31 | Final | W | 28 |
| 5 | 2025-10-04 | Indiana State (210) | 27 | Southern Illinois (146) | 55 | Final | W | 28 |
| 6 | 2025-10-11 | Southern Illinois (155) | 17 | North Dakota State (113) | 45 | Final | L | -28 |
| 7 | 2025-10-18 | North Dakota (139) | 38 | Southern Illinois (158) | 19 | Final | L | -19 |
| 8 | 2025-10-25 | Northern Iowa (219) | 17 | Southern Illinois (154) | 31 | Final | W | 14 |
| 9 | 2025-11-01 | Southern Illinois (151) | 27 | Murray State (252) | 7 | Final | W | 20 |
| 10 | 2025-11-08 | Southern Illinois (162) | 38 | Youngstown State (156) | 48 | Final | L | -10 |
| 11 | 2025-11-15 | South Dakota (153) | 53 | Southern Illinois (170) | 51 | Final/5OT | L | -2 |
| 12 | 2025-11-22 | Southern Illinois (160) | 37 | Illinois State (159) | 7 | Final | W | 30 |