Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Southeast Missouri State (158) | 24 | Arkansas State (89) | 42 | Final | L | -18 |
| 2 | 2025-09-06 | North Alabama (205) | 21 | Southeast Missouri State (158) | 30 | Final | W | 9 |
| 3 | 2025-09-13 | Southeast Missouri State (158) | 14 | North Dakota State (69) | 41 | Final | L | -27 |
| 4 | 2025-09-20 | Southern Illinois (152) | 59 | Southeast Missouri State (206) | 31 | Final | L | -28 |
| 5 | 2025-09-27 | Southeast Missouri State (225) | 10 | Tennessee-Martin (194) | 34 | Final | L | -24 |
| 6 | 2025-10-11 | Tennessee State (245) | 12 | Southeast Missouri State (222) | 28 | Final | W | 16 |
| 7 | 2025-10-18 | Eastern Illinois (232) | 13 | Southeast Missouri State (191) | 42 | Final | W | 29 |
| 8 | 2025-10-25 | Southeast Missouri State (197) | 23 | Tennessee Tech (129) | 42 | Final | L | -19 |
| 9 | 2025-11-01 | Charleston Southern (194) | 23 | Southeast Missouri State (213) | 17 | Final | L | -6 |
| 10 | 2025-11-08 | Southeast Missouri State (213) | 24 | Gardner-Webb (164) | 27 | Final | L | -3 |
| 11 | 2025-11-15 | Southeast Missouri State (212) | 22 | Western Illinois (239) | 17 | Final | W | 5 |
| 12 | 2025-11-22 | Lindenwood (181) | 30 | Southeast Missouri State (217) | 13 | Final | L | -17 |