Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-31 | Virginia Tech (45) | 11 | South Carolina (13) | 24 | Final | W | 13 |
| 2 | 2025-09-06 | South Carolina State (154) | 10 | South Carolina (13) | 38 | Final | W | 28 |
| 3 | 2025-09-13 | Vanderbilt (40) | 31 | South Carolina (13) | 7 | Final | L | -24 |
| 4 | 2025-09-20 | South Carolina (75) | 20 | Missouri (7) | 29 | Final | L | -9 |
| 5 | 2025-09-27 | Kentucky (64) | 13 | South Carolina (47) | 35 | Final | W | 22 |
| 6 | 2025-10-11 | South Carolina (63) | 10 | LSU (14) | 20 | Final | L | -10 |
| 7 | 2025-10-18 | Oklahoma (16) | 26 | South Carolina (66) | 7 | Final | L | -19 |
| 8 | 2025-10-25 | Alabama (5) | 29 | South Carolina (68) | 22 | Final | L | -7 |
| 9 | 2025-11-01 | South Carolina (67) | 14 | Ole Miss (6) | 30 | Final | L | -16 |
| 10 | 2025-11-15 | South Carolina (65) | 30 | Texas A&M (3) | 31 | Final | L | -1 |
| 11 | 2025-11-22 | Coastal Carolina (101) | 7 | South Carolina (53) | 51 | Final | W | 44 |
| 12 | 2025-11-29 | Clemson (53) | 28 | South Carolina (65) | 14 | Final | L | -14 |