Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Morgan State (212) | 21 | South Alabama (68) | 38 | Final | W | 17 |
| 2 | 2025-09-06 | Tulane (36) | 33 | South Alabama (68) | 31 | Final | L | -2 |
| 3 | 2025-09-13 | South Alabama (68) | 15 | Auburn (57) | 31 | Final | L | -16 |
| 4 | 2025-09-20 | Coastal Carolina (110) | 38 | South Alabama (122) | 20 | Final | L | -18 |
| 5 | 2025-09-27 | South Alabama (119) | 22 | North Texas (15) | 36 | Final | L | -14 |
| 6 | 2025-10-04 | South Alabama (129) | 24 | Troy (84) | 31 | Final/OT | L | -7 |
| 7 | 2025-10-14 | Arkansas State (116) | 15 | South Alabama (128) | 14 | Final | L | -1 |
| 8 | 2025-10-23 | South Alabama (123) | 38 | Georgia State (143) | 31 | Final | W | 7 |
| 9 | 2025-11-01 | Louisiana (123) | 31 | South Alabama (131) | 22 | Final | L | -9 |
| 10 | 2025-11-15 | South Alabama (120) | 26 | Louisiana-Monroe (130) | 14 | Final | W | 12 |
| 11 | 2025-11-22 | Southern Miss (81) | 35 | South Alabama (113) | 42 | Final | W | 7 |
| 12 | 2025-11-29 | South Alabama (119) | 26 | Texas State (90) | 49 | Final | L | -23 |