Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Ball State (130) | 0 | Purdue (133) | 31 | Final | W | 31 |
| 2 | 2025-09-06 | Southern Illinois (184) | 17 | Purdue (133) | 34 | Final | W | 17 |
| 3 | 2025-09-13 | USC (30) | 33 | Purdue (133) | 17 | Final | L | -16 |
| 4 | 2025-09-20 | Purdue (95) | 30 | Notre Dame (57) | 56 | Final | L | -26 |
| 5 | 2025-10-04 | Illinois (14) | 43 | Purdue (83) | 27 | Final | L | -16 |
| 6 | 2025-10-11 | Purdue (90) | 20 | Minnesota (46) | 27 | Final | L | -7 |
| 7 | 2025-10-18 | Purdue (95) | 0 | Northwestern (42) | 19 | Final | L | -19 |
| 8 | 2025-10-25 | Rutgers (66) | 27 | Purdue (109) | 24 | Final | L | -3 |
| 9 | 2025-11-01 | Purdue (109) | 16 | Michigan (19) | 21 | Final | L | -5 |
| 10 | 2025-11-08 | Ohio State (2) | 34 | Purdue (107) | 10 | Final | L | -24 |
| 11 | 2025-11-15 | Purdue (108) | 13 | Washington (25) | 49 | Final | L | -36 |
| 12 | 2025-11-28 | Indiana (1) | 56 | Purdue (111) | 3 | Final | L | -53 |