Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Duquesne (176) | 9 | Pittsburgh (55) | 61 | Final | W | 52 |
| 2 | 2025-09-06 | Central Michigan (122) | 17 | Pittsburgh (55) | 45 | Final | W | 28 |
| 3 | 2025-09-13 | Pittsburgh (55) | 24 | West Virginia (67) | 31 | Final/OT | L | -7 |
| 4 | 2025-09-27 | Louisville (19) | 34 | Pittsburgh (77) | 27 | Final | L | -7 |
| 5 | 2025-10-04 | Boston College (121) | 7 | Pittsburgh (68) | 48 | Final | W | 41 |
| 6 | 2025-10-11 | Pittsburgh (50) | 34 | Florida State (39) | 31 | Final | W | 3 |
| 7 | 2025-10-18 | Pittsburgh (41) | 30 | Syracuse (80) | 13 | Final | W | 17 |
| 8 | 2025-10-25 | North Carolina State (55) | 34 | Pittsburgh (36) | 53 | Final | W | 19 |
| 9 | 2025-11-01 | Pittsburgh (29) | 35 | Stanford (88) | 20 | Final | W | 15 |
| 10 | 2025-11-15 | Notre Dame (9) | 37 | Pittsburgh (38) | 15 | Final | L | -22 |
| 11 | 2025-11-22 | Pittsburgh (27) | 42 | Georgia Tech (28) | 28 | Final | W | 14 |
| 12 | 2025-11-29 | Miami (13) | 38 | Pittsburgh (33) | 7 | Final | L | -31 |
| 13 | 2025-12-27 | Pittsburgh (33) | 17 | East Carolina (43) | 23 | Final | L | -6 |