Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-28 | Tennessee-Martin (137) | 7 | Oklahoma State (110) | 27 | Final | W | 20 |
| 2 | 2025-09-06 | Oklahoma State (110) | 3 | Oregon (2) | 69 | Final | L | -66 |
| 3 | 2025-09-19 | Tulsa (96) | 19 | Oklahoma State (116) | 12 | Final | L | -7 |
| 4 | 2025-09-27 | Baylor (71) | 45 | Oklahoma State (125) | 27 | Final | L | -18 |
| 5 | 2025-10-04 | Oklahoma State (133) | 13 | Arizona (43) | 41 | Final | L | -28 |
| 6 | 2025-10-11 | Houston (38) | 39 | Oklahoma State (132) | 17 | Final | L | -22 |
| 7 | 2025-10-18 | Cincinnati (21) | 49 | Oklahoma State (136) | 17 | Final | L | -32 |
| 8 | 2025-10-25 | Oklahoma State (139) | 0 | Texas Tech (11) | 42 | Final | L | -42 |
| 9 | 2025-11-01 | Oklahoma State (137) | 21 | Kansas (55) | 38 | Final | L | -17 |
| 10 | 2025-11-15 | Kansas State (63) | 14 | Oklahoma State (141) | 6 | Final | L | -8 |
| 11 | 2025-11-22 | Oklahoma State (141) | 14 | Central Florida (76) | 17 | Final | L | -3 |
| 12 | 2025-11-29 | Iowa State (35) | 20 | Oklahoma State (144) | 13 | Final | L | -7 |