Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Texas (4) | 7 | Ohio State (1) | 14 | Final | W | 7 |
| 2 | 2025-09-06 | Grambling (231) | 0 | Ohio State (1) | 70 | Final | W | 70 |
| 3 | 2025-09-13 | Ohio (42) | 9 | Ohio State (1) | 37 | Final | W | 28 |
| 4 | 2025-09-27 | Ohio State (3) | 24 | Washington (35) | 6 | Final | W | 18 |
| 5 | 2025-10-04 | Minnesota (53) | 3 | Ohio State (4) | 42 | Final | W | 39 |
| 6 | 2025-10-11 | Ohio State (2) | 34 | Illinois (13) | 16 | Final | W | 18 |
| 7 | 2025-10-18 | Ohio State (2) | 34 | Wisconsin (94) | 0 | Final | W | 34 |
| 8 | 2025-11-01 | Penn State (80) | 14 | Ohio State (2) | 38 | Final | W | 24 |
| 9 | 2025-11-08 | Ohio State (2) | 34 | Purdue (107) | 10 | Final | W | 24 |
| 10 | 2025-11-15 | UCLA (87) | 10 | Ohio State (2) | 48 | Final | W | 38 |
| 11 | 2025-11-22 | Rutgers (70) | 9 | Ohio State (2) | 42 | Final | W | 33 |
| 12 | 2025-11-29 | Ohio State (2) | 27 | Michigan (18) | 9 | Final | W | 18 |
| 13 | 2025-12-06 | Indiana | 13 | Ohio State | 10 | Final | L | -3 |
| 14 | 2025-12-31 | Miami (13) | 24 | Ohio State (2) | 14 | Final | L | -10 |