Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-31 | Notre Dame (3) | 24 | Miami (15) | 27 | Final | L | -3 |
| 2 | 2025-09-13 | Texas A&M (26) | 41 | Notre Dame (3) | 40 | Final | L | -1 |
| 3 | 2025-09-20 | Purdue (95) | 30 | Notre Dame (57) | 56 | Final | W | 26 |
| 4 | 2025-09-27 | Notre Dame (33) | 56 | Arkansas (79) | 13 | Final | W | 43 |
| 5 | 2025-10-04 | Boise State (66) | 7 | Notre Dame (23) | 28 | Final | W | 21 |
| 6 | 2025-10-11 | North Carolina State (49) | 7 | Notre Dame (10) | 36 | Final | W | 29 |
| 7 | 2025-10-18 | USC (20) | 24 | Notre Dame (8) | 34 | Final | W | 10 |
| 8 | 2025-11-01 | Notre Dame (11) | 25 | Boston College (135) | 10 | Final | W | 15 |
| 9 | 2025-11-08 | Navy (45) | 10 | Notre Dame (10) | 49 | Final | W | 39 |
| 10 | 2025-11-15 | Notre Dame (9) | 37 | Pittsburgh (38) | 15 | Final | W | 22 |
| 11 | 2025-11-22 | Syracuse (99) | 7 | Notre Dame (8) | 70 | Final | W | 63 |
| 12 | 2025-11-29 | Notre Dame (8) | 49 | Stanford (87) | 20 | Final | W | 29 |