Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Northwestern (90) | 3 | Tulane (36) | 23 | Final | L | -20 |
| 2 | 2025-09-05 | Western Illinois (223) | 7 | Northwestern (90) | 42 | Final | W | 35 |
| 3 | 2025-09-13 | Oregon (2) | 34 | Northwestern (90) | 14 | Final | L | -20 |
| 4 | 2025-09-27 | UCLA (126) | 14 | Northwestern (84) | 17 | Final | W | 3 |
| 5 | 2025-10-04 | Louisiana-Monroe (90) | 7 | Northwestern (58) | 42 | Final | W | 35 |
| 6 | 2025-10-11 | Northwestern (48) | 22 | Penn State (80) | 21 | Final | W | 1 |
| 7 | 2025-10-18 | Purdue (95) | 0 | Northwestern (42) | 19 | Final | W | 19 |
| 8 | 2025-10-25 | Northwestern (51) | 21 | Nebraska (31) | 28 | Final | L | -7 |
| 9 | 2025-11-07 | Northwestern (55) | 17 | USC (12) | 38 | Final | L | -21 |
| 10 | 2025-11-15 | Michigan (15) | 24 | Northwestern (53) | 22 | Final | L | -2 |
| 11 | 2025-11-22 | Minnesota (60) | 35 | Northwestern (49) | 38 | Final | W | 3 |
| 12 | 2025-11-29 | Northwestern (54) | 13 | Illinois (25) | 20 | Final | L | -7 |
| 13 | 2025-12-26 | Central Michigan (99) | 7 | Northwestern (54) | 34 | Final | W | 27 |