Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Holy Cross (180) | 17 | Northern Illinois (71) | 19 | Final | W | 2 |
| 2 | 2025-09-05 | Northern Illinois (71) | 9 | Maryland (84) | 20 | Final | L | -11 |
| 3 | 2025-09-20 | Northern Illinois (105) | 10 | Mississippi State (6) | 38 | Final | L | -28 |
| 4 | 2025-09-27 | San Diego State (55) | 6 | Northern Illinois (111) | 3 | Final | L | -3 |
| 5 | 2025-10-04 | Miami (OH) (106) | 25 | Northern Illinois (128) | 14 | Final | L | -11 |
| 6 | 2025-10-11 | Northern Illinois (138) | 10 | Eastern Michigan (136) | 16 | Final | L | -6 |
| 7 | 2025-10-18 | Northern Illinois (143) | 21 | Ohio (85) | 48 | Final | L | -27 |
| 8 | 2025-10-25 | Ball State (131) | 7 | Northern Illinois (134) | 21 | Final | W | 14 |
| 9 | 2025-11-05 | Northern Illinois (135) | 3 | Toledo (77) | 42 | Final | L | -39 |
| 10 | 2025-11-12 | Northern Illinois (134) | 45 | Massachusetts (207) | 3 | Final | W | 42 |
| 11 | 2025-11-18 | Western Michigan (72) | 35 | Northern Illinois (136) | 19 | Final | L | -16 |
| 12 | 2025-11-28 | Kent State (125) | 35 | Northern Illinois (141) | 31 | Final | L | -4 |