Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-23 | Incarnate Word (131) | 6 | Nicholls State (207) | 20 | Final | W | 14 |
| 2 | 2025-08-30 | Nicholls State (207) | 20 | Troy (112) | 38 | Final | L | -18 |
| 3 | 2025-09-06 | West Georgia (221) | 34 | Nicholls State (207) | 10 | Final | L | -24 |
| 4 | 2025-09-20 | Nicholls State (190) | 3 | Texas State (60) | 35 | Final | L | -32 |
| 5 | 2025-09-27 | Nicholls State (212) | 7 | Eastern Kentucky (184) | 27 | Final | L | -20 |
| 6 | 2025-10-04 | Nicholls State (216) | 17 | Lamar (151) | 24 | Final | L | -7 |
| 7 | 2025-10-18 | Nicholls State (224) | 7 | Stephen F. Austin (161) | 34 | Final | L | -27 |
| 8 | 2025-10-25 | McNeese (235) | 7 | Nicholls State (218) | 31 | Final | W | 24 |
| 9 | 2025-11-01 | Houston Christian (247) | 7 | Nicholls State (202) | 31 | Final | W | 24 |
| 10 | 2025-11-08 | Nicholls State (205) | 21 | UTRGV (163) | 28 | Final | L | -7 |
| 11 | 2025-11-15 | Northwestern State (257) | 21 | Nicholls State (203) | 26 | Final | W | 5 |
| 12 | 2025-11-20 | Nicholls State (209) | 26 | Southeastern Louisiana (147) | 38 | Final | L | -12 |