Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Murray State (251) | 17 | East Tennessee State (170) | 45 | Final | L | -28 |
| 2 | 2025-09-06 | Southeastern Louisiana (155) | 45 | Murray State (251) | 24 | Final | L | -21 |
| 3 | 2025-09-13 | Murray State (251) | 21 | Georgia State (116) | 37 | Final | L | -16 |
| 4 | 2025-09-20 | Murray State (246) | 10 | Jacksonville State (97) | 45 | Final | L | -35 |
| 5 | 2025-10-04 | Murray State (244) | 24 | South Dakota (180) | 49 | Final | L | -25 |
| 6 | 2025-10-11 | Illinois State (169) | 46 | Murray State (241) | 32 | Final | L | -14 |
| 7 | 2025-10-18 | South Dakota State (118) | 35 | Murray State (244) | 14 | Final | L | -21 |
| 8 | 2025-10-25 | Murray State (252) | 17 | Youngstown State (159) | 51 | Final | L | -34 |
| 9 | 2025-11-01 | Southern Illinois (151) | 27 | Murray State (252) | 7 | Final | L | -20 |
| 10 | 2025-11-08 | Murray State (254) | 14 | Northern Iowa (221) | 31 | Final | L | -17 |
| 11 | 2025-11-15 | North Dakota (143) | 35 | Murray State (253) | 17 | Final | L | -18 |
| 12 | 2025-11-22 | Murray State (243) | 31 | Indiana State (230) | 17 | Final | W | 14 |