Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Missouri State (134) | 13 | USC (30) | 73 | Final | L | -60 |
| 2 | 2025-09-06 | Missouri State (134) | 21 | Marshall (37) | 20 | Final | W | 1 |
| 3 | 2025-09-13 | SMU (12) | 28 | Missouri State (134) | 10 | Final | L | -18 |
| 4 | 2025-09-20 | Tennessee-Martin (219) | 10 | Missouri State (111) | 42 | Final | W | 32 |
| 5 | 2025-09-27 | Western Kentucky (69) | 27 | Missouri State (113) | 22 | Final | L | -5 |
| 6 | 2025-10-08 | Missouri State (101) | 22 | Middle Tennessee (149) | 20 | Final | W | 2 |
| 7 | 2025-10-22 | Missouri State (95) | 24 | New Mexico State (121) | 17 | Final/OT | W | 7 |
| 8 | 2025-10-29 | Florida International (114) | 21 | Missouri State (84) | 28 | Final | W | 7 |
| 9 | 2025-11-08 | Missouri State (75) | 21 | Liberty (109) | 17 | Final | W | 4 |
| 10 | 2025-11-15 | UTEP (137) | 24 | Missouri State (71) | 38 | Final | W | 14 |
| 11 | 2025-11-22 | Missouri State (75) | 34 | Kennesaw State (54) | 41 | Final | L | -7 |
| 12 | 2025-11-29 | Louisiana Tech (83) | 42 | Missouri State (92) | 30 | Final | L | -12 |
| 13 | 2025-12-18 | Missouri State (92) | 28 | Arkansas State (101) | 34 | Final | L | -6 |