Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-29 | Western Michigan (104) | 6 | Michigan State (72) | 23 | Final | W | 17 |
| 2 | 2025-09-06 | Boston College (51) | 40 | Michigan State (72) | 42 | Final/2OT | W | 2 |
| 3 | 2025-09-13 | Youngstown State (191) | 24 | Michigan State (72) | 41 | Final | W | 17 |
| 4 | 2025-09-20 | Michigan State (13) | 31 | USC (29) | 45 | Final | L | -14 |
| 5 | 2025-10-04 | Michigan State (63) | 27 | Nebraska (17) | 38 | Final | L | -11 |
| 6 | 2025-10-11 | UCLA (87) | 38 | Michigan State (86) | 13 | Final | L | -25 |
| 7 | 2025-10-18 | Michigan State (86) | 13 | Indiana (1) | 38 | Final | L | -25 |
| 8 | 2025-10-25 | Michigan (17) | 31 | Michigan State (91) | 20 | Final | L | -11 |
| 9 | 2025-11-01 | Michigan State (95) | 20 | Minnesota (48) | 23 | Final/OT | L | -3 |
| 10 | 2025-11-15 | Penn State (62) | 28 | Michigan State (101) | 10 | Final | L | -18 |
| 11 | 2025-11-22 | Michigan State (100) | 17 | Iowa (26) | 20 | Final | L | -3 |
| 12 | 2025-11-29 | Maryland (95) | 28 | Michigan State (89) | 38 | Final | W | 10 |