Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Temple (126) | 42 | Massachusetts (141) | 10 | Final | L | -32 |
| 2 | 2025-09-06 | Bryant (248) | 27 | Massachusetts (141) | 26 | Final | L | -1 |
| 3 | 2025-09-13 | Massachusetts (141) | 7 | Iowa (33) | 47 | Final | L | -40 |
| 4 | 2025-09-27 | Massachusetts (156) | 6 | Missouri (11) | 42 | Final | L | -36 |
| 5 | 2025-10-04 | Western Michigan (85) | 21 | Massachusetts (165) | 3 | Final | L | -18 |
| 6 | 2025-10-11 | Massachusetts (176) | 6 | Kent State (126) | 42 | Final | L | -36 |
| 7 | 2025-10-18 | Buffalo (100) | 28 | Massachusetts (178) | 21 | Final | L | -7 |
| 8 | 2025-10-25 | Massachusetts (184) | 13 | Central Michigan (98) | 38 | Final | L | -25 |
| 9 | 2025-11-04 | Massachusetts (199) | 10 | Akron (126) | 44 | Final | L | -34 |
| 10 | 2025-11-12 | Northern Illinois (134) | 45 | Massachusetts (207) | 3 | Final | L | -42 |
| 11 | 2025-11-18 | Massachusetts (211) | 14 | Ohio (78) | 42 | Final | L | -28 |
| 12 | 2025-11-25 | Bowling Green (129) | 45 | Massachusetts (216) | 14 | Final | L | -31 |