Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-28 | St. Francis | 0 | Louisiana-Monroe (106) | 29 | Final | W | 29 |
| 2 | 2025-09-06 | Louisiana-Monroe (106) | 0 | Alabama (10) | 73 | Final | L | -73 |
| 3 | 2025-09-20 | Louisiana-Monroe (83) | 31 | UTEP (119) | 25 | Final | W | 6 |
| 4 | 2025-09-27 | Arkansas State (128) | 16 | Louisiana-Monroe (78) | 28 | Final | W | 12 |
| 5 | 2025-10-04 | Louisiana-Monroe (90) | 7 | Northwestern (58) | 42 | Final | L | -35 |
| 6 | 2025-10-11 | Louisiana-Monroe (108) | 8 | Coastal Carolina (104) | 23 | Final | L | -15 |
| 7 | 2025-10-18 | Troy (69) | 37 | Louisiana-Monroe (115) | 14 | Final | L | -23 |
| 8 | 2025-10-25 | Louisiana-Monroe (116) | 21 | Southern Miss (60) | 49 | Final | L | -28 |
| 9 | 2025-11-01 | Old Dominion (49) | 31 | Louisiana-Monroe (122) | 6 | Final | L | -25 |
| 10 | 2025-11-15 | South Alabama (120) | 26 | Louisiana-Monroe (130) | 14 | Final | L | -12 |
| 11 | 2025-11-22 | Louisiana-Monroe (134) | 14 | Texas State (97) | 31 | Final | L | -17 |
| 12 | 2025-11-29 | Louisiana-Monroe (135) | 27 | Louisiana (100) | 30 | Final/OT | L | -3 |