Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-28 | McKendree | 24 | Indiana State (222) | 41 | Final | W | 17 |
| 2 | 2025-09-06 | Eastern Illinois (226) | 14 | Indiana State (222) | 38 | Final | W | 24 |
| 3 | 2025-09-12 | Indiana State (222) | 0 | Indiana (6) | 73 | Final | L | -73 |
| 4 | 2025-09-20 | Indiana State (204) | 20 | Montana (146) | 63 | Final | L | -43 |
| 5 | 2025-10-04 | Indiana State (210) | 27 | Southern Illinois (146) | 55 | Final | L | -28 |
| 6 | 2025-10-11 | South Dakota (167) | 19 | Indiana State (228) | 14 | Final | L | -5 |
| 7 | 2025-10-18 | North Dakota State (113) | 38 | Indiana State (231) | 7 | Final | L | -31 |
| 8 | 2025-10-25 | Indiana State (230) | 17 | North Dakota (137) | 46 | Final | L | -29 |
| 9 | 2025-11-01 | Indiana State (206) | 24 | South Dakota State (139) | 12 | Final | W | 12 |
| 10 | 2025-11-08 | Illinois State (154) | 52 | Indiana State (212) | 20 | Final | L | -32 |
| 11 | 2025-11-15 | Indiana State (216) | 29 | Youngstown State (155) | 48 | Final | L | -19 |
| 12 | 2025-11-22 | Murray State (243) | 31 | Indiana State (230) | 17 | Final | L | -14 |