Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-28 | Stephen F. Austin (163) | 0 | Houston (87) | 27 | Final | W | 27 |
| 2 | 2025-09-06 | Houston (87) | 35 | Rice (101) | 9 | Final | W | 26 |
| 3 | 2025-09-12 | Colorado (35) | 20 | Houston (87) | 36 | Final | W | 16 |
| 4 | 2025-09-26 | Houston (16) | 27 | Oregon State (115) | 24 | Final/OT | W | 3 |
| 5 | 2025-10-04 | Texas Tech (7) | 35 | Houston (42) | 11 | Final | L | -24 |
| 6 | 2025-10-11 | Houston (38) | 39 | Oklahoma State (132) | 17 | Final | W | 22 |
| 7 | 2025-10-18 | Arizona (52) | 28 | Houston (33) | 31 | Final | W | 3 |
| 8 | 2025-10-25 | Houston (26) | 24 | Arizona State (42) | 16 | Final | W | 8 |
| 9 | 2025-11-01 | West Virginia (89) | 45 | Houston (37) | 35 | Final | L | -10 |
| 10 | 2025-11-07 | Houston (31) | 30 | Central Florida (70) | 27 | Final | W | 3 |
| 11 | 2025-11-22 | TCU (39) | 17 | Houston (38) | 14 | Final | L | -3 |
| 12 | 2025-11-29 | Houston (36) | 31 | Baylor (73) | 24 | Final | W | 7 |
| 13 | 2025-12-27 | LSU (31) | 35 | Houston (36) | 38 | Final | W | 3 |