Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Eastern Michigan (117) | 27 | Texas State (58) | 52 | Final | L | -25 |
| 2 | 2025-09-06 | Long Island (237) | 28 | Eastern Michigan (117) | 23 | Final | L | -5 |
| 3 | 2025-09-13 | Eastern Michigan (117) | 23 | Kentucky (63) | 48 | Final | L | -25 |
| 4 | 2025-09-20 | Louisiana (130) | 31 | Eastern Michigan (135) | 34 | Final | W | 3 |
| 5 | 2025-09-27 | Eastern Michigan (140) | 13 | Central Michigan (100) | 24 | Final | L | -11 |
| 6 | 2025-10-04 | Eastern Michigan (145) | 30 | Buffalo (97) | 31 | Final/OT | L | -1 |
| 7 | 2025-10-11 | Northern Illinois (138) | 10 | Eastern Michigan (136) | 16 | Final | W | 6 |
| 8 | 2025-10-18 | Eastern Michigan (141) | 30 | Miami (OH) (106) | 44 | Final | L | -14 |
| 9 | 2025-10-25 | Ohio (80) | 28 | Eastern Michigan (142) | 21 | Final | L | -7 |
| 10 | 2025-11-08 | Bowling Green (128) | 21 | Eastern Michigan (133) | 27 | Final | W | 6 |
| 11 | 2025-11-15 | Eastern Michigan (125) | 24 | Ball State (128) | 9 | Final | W | 15 |
| 12 | 2025-11-25 | Western Michigan (70) | 31 | Eastern Michigan (127) | 21 | Final | L | -10 |