Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Eastern Kentucky (162) | 17 | Louisville (20) | 51 | Final | L | -34 |
| 2 | 2025-09-06 | Houston Christian (200) | 10 | Eastern Kentucky (162) | 20 | Final | W | 10 |
| 3 | 2025-09-13 | Eastern Kentucky (162) | 7 | Marshall (37) | 38 | Final | L | -31 |
| 4 | 2025-09-20 | Eastern Kentucky (198) | 12 | West Georgia (138) | 33 | Final | L | -21 |
| 5 | 2025-09-27 | Nicholls State (212) | 7 | Eastern Kentucky (184) | 27 | Final | W | 20 |
| 6 | 2025-10-11 | Austin Peay (151) | 20 | Eastern Kentucky (166) | 34 | Final | W | 14 |
| 7 | 2025-10-18 | Eastern Kentucky (189) | 14 | North Alabama (237) | 35 | Final | L | -21 |
| 8 | 2025-10-25 | Tarleton State (89) | 31 | Eastern Kentucky (192) | 7 | Final | L | -24 |
| 9 | 2025-11-01 | Eastern Kentucky (185) | 34 | Central Arkansas (223) | 13 | Final | W | 21 |
| 10 | 2025-11-08 | Southern Utah (169) | 27 | Eastern Kentucky (196) | 17 | Final | L | -10 |
| 11 | 2025-11-15 | Abilene Christian (146) | 17 | Eastern Kentucky (196) | 10 | Final | L | -7 |
| 12 | 2025-11-22 | Eastern Kentucky (191) | 33 | Utah Tech (240) | 10 | Final | W | 23 |