Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-28 | Dayton (233) | 14 | Eastern Illinois (226) | 24 | Final | W | 10 |
| 2 | 2025-09-06 | Eastern Illinois (226) | 14 | Indiana State (222) | 38 | Final | L | -24 |
| 3 | 2025-09-13 | Illinois State (139) | 42 | Eastern Illinois (226) | 30 | Final | L | -12 |
| 4 | 2025-09-27 | Eastern Illinois (211) | 31 | Western Illinois (251) | 23 | Final | W | 8 |
| 5 | 2025-10-04 | Tennessee State (240) | 7 | Eastern Illinois (199) | 31 | Final | W | 24 |
| 6 | 2025-10-11 | Gardner-Webb (153) | 21 | Eastern Illinois (213) | 10 | Final | L | -11 |
| 7 | 2025-10-18 | Eastern Illinois (232) | 13 | Southeast Missouri State (191) | 42 | Final | L | -29 |
| 8 | 2025-10-25 | Eastern Illinois (229) | 16 | Charleston Southern (202) | 17 | Final | L | -1 |
| 9 | 2025-11-01 | Tennessee-Martin (175) | 27 | Eastern Illinois (230) | 20 | Final/OT | L | -7 |
| 10 | 2025-11-08 | Tennessee Tech (124) | 21 | Eastern Illinois (227) | 9 | Final | L | -12 |
| 11 | 2025-11-15 | Eastern Illinois (234) | 12 | Lindenwood (187) | 42 | Final | L | -30 |
| 12 | 2025-11-22 | Eastern Illinois (238) | 0 | Alabama (10) | 56 | Final | L | -56 |