Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-28 | East Carolina (78) | 17 | North Carolina State (83) | 24 | Final | L | -7 |
| 2 | 2025-09-06 | Campbell (229) | 3 | East Carolina (78) | 56 | Final | W | 53 |
| 3 | 2025-09-13 | East Carolina (78) | 38 | Coastal Carolina (99) | 0 | Final | W | 38 |
| 4 | 2025-09-20 | BYU (16) | 34 | East Carolina (64) | 13 | Final | L | -21 |
| 5 | 2025-09-25 | Army (120) | 6 | East Carolina (66) | 28 | Final | W | 22 |
| 6 | 2025-10-09 | East Carolina (64) | 19 | Tulane (21) | 26 | Final | L | -7 |
| 7 | 2025-10-16 | Tulsa (123) | 27 | East Carolina (54) | 41 | Final | W | 14 |
| 8 | 2025-11-01 | East Carolina (42) | 45 | Temple (74) | 14 | Final | W | 31 |
| 9 | 2025-11-08 | Charlotte (149) | 22 | East Carolina (43) | 48 | Final | W | 26 |
| 10 | 2025-11-15 | Memphis (42) | 27 | East Carolina (37) | 31 | Final | W | 4 |
| 11 | 2025-11-22 | East Carolina (45) | 24 | UTSA (62) | 58 | Final | L | -34 |
| 12 | 2025-11-29 | East Carolina (43) | 42 | Florida Atlantic (108) | 3 | Final | W | 39 |
| 13 | 2025-12-27 | Pittsburgh (33) | 17 | East Carolina (43) | 23 | Final | W | 6 |