Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Duquesne (176) | 9 | Pittsburgh (55) | 61 | Final | L | -52 |
| 2 | 2025-09-06 | Lincoln (PA) | 14 | Duquesne (176) | 55 | Final | W | 41 |
| 3 | 2025-09-13 | Lehigh (161) | 35 | Duquesne (176) | 21 | Final | L | -14 |
| 4 | 2025-09-20 | Duquesne (210) | 7 | Akron (128) | 51 | Final | L | -44 |
| 5 | 2025-09-27 | New Haven (256) | 18 | Duquesne (197) | 44 | Final | W | 26 |
| 6 | 2025-10-04 | Stonehill (222) | 14 | Duquesne (178) | 34 | Final | W | 20 |
| 7 | 2025-10-11 | St. Francis | 7 | Duquesne (173) | 52 | Final | W | 45 |
| 8 | 2025-10-18 | Duquesne (164) | 37 | Mercyhurst (211) | 0 | Final | W | 37 |
| 9 | 2025-10-25 | Duquesne (188) | 13 | Wagner (238) | 24 | Final | L | -11 |
| 10 | 2025-11-08 | Duquesne (204) | 11 | Long Island (206) | 29 | Final | L | -18 |
| 11 | 2025-11-15 | Central Connecticut State (185) | 33 | Duquesne (190) | 38 | Final | W | 5 |
| 12 | 2025-11-22 | Duquesne (187) | 20 | Robert Morris (251) | 17 | Final | W | 3 |