Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-28 | Elon (183) | 17 | Duke (44) | 45 | Final | W | 28 |
| 2 | 2025-09-06 | Illinois (17) | 45 | Duke (44) | 19 | Final | L | -26 |
| 3 | 2025-09-13 | Duke (44) | 27 | Tulane (36) | 34 | Final | L | -7 |
| 4 | 2025-09-20 | North Carolina State (37) | 33 | Duke (67) | 45 | Final | W | 12 |
| 5 | 2025-09-27 | Duke (46) | 38 | Syracuse (68) | 3 | Final | W | 35 |
| 6 | 2025-10-04 | Duke (56) | 45 | California (44) | 21 | Final | W | 24 |
| 7 | 2025-10-18 | Georgia Tech (7) | 27 | Duke (40) | 18 | Final | L | -9 |
| 8 | 2025-11-01 | Duke (45) | 46 | Clemson (79) | 45 | Final | W | 1 |
| 9 | 2025-11-08 | Duke (52) | 34 | Connecticut (65) | 37 | Final | L | -3 |
| 10 | 2025-11-15 | Virginia (22) | 34 | Duke (50) | 17 | Final | L | -17 |
| 11 | 2025-11-22 | Duke (52) | 32 | North Carolina (106) | 25 | Final | W | 7 |
| 12 | 2025-11-29 | Wake Forest (46) | 32 | Duke (45) | 49 | Final | W | 17 |
| 13 | 2025-12-06 | Duke | 27 | Virginia | 20 | Final/OT | W | 7 |
| 14 | 2025-12-31 | Arizona State (32) | 39 | Duke (45) | 42 | Final | W | 3 |