Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-28 | Upper Iowa | 7 | Drake (177) | 41 | Final | W | 34 |
| 2 | 2025-09-13 | Drake (177) | 21 | South Dakota State (92) | 37 | Final | L | -16 |
| 3 | 2025-09-20 | Drake (230) | 21 | South Dakota (185) | 42 | Final | L | -21 |
| 4 | 2025-10-04 | Valparaiso (265) | 0 | Drake (213) | 41 | Final | W | 41 |
| 5 | 2025-10-11 | Drake (189) | 19 | San Diego (214) | 16 | Final | W | 3 |
| 6 | 2025-10-18 | Davidson (264) | 0 | Drake (183) | 45 | Final | W | 45 |
| 7 | 2025-10-25 | Drake (175) | 31 | Marist (233) | 17 | Final | W | 14 |
| 8 | 2025-11-01 | Drake (173) | 24 | Butler (220) | 19 | Final | W | 5 |
| 9 | 2025-11-08 | St. Thomas (182) | 20 | Drake (184) | 13 | Final | L | -7 |
| 10 | 2025-11-15 | Drake (179) | 14 | Dayton (214) | 6 | Final | W | 8 |
| 11 | 2025-11-22 | Morehead State (242) | 10 | Drake (177) | 17 | Final | W | 7 |
| 12 | 2025-11-29 | Drake (178) | 17 | South Dakota (147) | 38 | Final | L | -21 |