Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-29 | Georgia Tech (43) | 27 | Colorado (35) | 20 | Final | L | -7 |
| 2 | 2025-09-06 | Delaware (140) | 7 | Colorado (35) | 31 | Final | W | 24 |
| 3 | 2025-09-12 | Colorado (35) | 20 | Houston (87) | 36 | Final | L | -16 |
| 4 | 2025-09-20 | Wyoming (101) | 20 | Colorado (50) | 37 | Final | W | 17 |
| 5 | 2025-09-27 | BYU (34) | 24 | Colorado (31) | 21 | Final | L | -3 |
| 6 | 2025-10-04 | Colorado (70) | 21 | TCU (39) | 35 | Final | L | -14 |
| 7 | 2025-10-11 | Iowa State (36) | 17 | Colorado (54) | 24 | Final | W | 7 |
| 8 | 2025-10-25 | Colorado (56) | 7 | Utah (15) | 53 | Final | L | -46 |
| 9 | 2025-11-01 | Arizona (43) | 52 | Colorado (72) | 17 | Final | L | -35 |
| 10 | 2025-11-08 | Colorado (85) | 22 | West Virginia (73) | 29 | Final | L | -7 |
| 11 | 2025-11-22 | Arizona State (31) | 42 | Colorado (84) | 17 | Final | L | -25 |
| 12 | 2025-11-29 | Colorado (93) | 14 | Kansas State (61) | 24 | Final | L | -10 |