Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-11-03 | South Carolina State (211) | 45 | 104 | Louisville (18) | Final | W | 59 |
| 2 | 2025-11-06 | Jackson State (268) | 70 | 106 | Louisville (18) | Final | W | 36 |
| 3 | 2025-11-11 | Kentucky (9) | 88 | 96 | Louisville (18) | Final | W | 8 |
| 4 | 2025-11-15 | Ohio (181) | 81 | 106 | Louisville (18) | Final | W | 25 |
| 5 | 2025-11-21 | Louisville (18) | 74 | 64 | Cincinnati (59) | Final | W | 10 |
| 6 | 2025-11-24 | Eastern Michigan (244) | 46 | 87 | Louisville (18) | Final | W | 41 |
| 7 | 2025-11-26 | NJIT (353) | 47 | 104 | Louisville (18) | Final | W | 57 |
| 8 | 2025-12-03 | Louisville (10) | 80 | 89 | Arkansas (59) | Final | L | -9 |
| 9 | 2025-12-06 | Indiana (9) | 78 | 87 | Louisville (10) | Final | W | 9 |
| 10 | 2025-12-13 | Memphis (128) | 73 | 99 | Louisville (19) | Final | W | 26 |
| 11 | 2025-12-16 | Louisville (13) | 62 | 83 | Tennessee (54) | Final | L | -21 |
| 12 | 2025-12-20 | Montana (214) | 54 | 94 | Louisville (13) | Final | W | 40 |
| 13 | 2025-12-30 | Louisville (28) | 90 | 70 | California (40) | Final | W | 20 |
| 14 | 2026-01-02 | Louisville (28) | 76 | 80 | Stanford (53) | Final | L | -4 |
| 15 | 2026-01-06 | Duke (9) | 84 | 73 | Louisville (28) | Final | L | -11 |
| 16 | 2026-01-10 | Boston College (180) | 62 | 75 | Louisville (28) | Final | W | 13 |
| 17 | 2026-01-13 | Virginia (18) | 79 | 70 | Louisville (31) | Final | L | -9 |
| 18 | 2026-01-17 | Louisville (31) | 100 | 59 | Pittsburgh (119) | Final | W | 41 |
| 19 | 2026-01-24 | Virginia Tech (43) | 71 | 85 | Louisville (24) | Final | W | 14 |
| 20 | 2026-01-26 | Louisville (22) | 52 | 83 | Duke (3) | Final | L | -31 |
| 21 | 2026-01-31 | SMU (24) | 74 | 88 | Louisville (22) | Final | W | 14 |
| 22 | 2026-02-04 | Notre Dame (83) | 65 | 76 | Louisville (22) | Final | W | 11 |
| 23 | 2026-02-07 | Louisville (22) | 88 | 80 | Wake Forest (75) | Final | W | 8 |
| 24 | 2026-02-09 | North Carolina State (30) | 77 | 118 | Louisville (23) | Final | W | 41 |
| 25 | 2026-02-14 | Louisville (23) | 82 | 71 | Baylor (53) | Final | W | 11 |
| 26 | 2026-02-17 | Louisville (18) | 85 | 95 | SMU (36) | Final | L | -10 |
| 27 | 2026-02-21 | Georgia Tech (148) | 70 | 87 | Louisville (18) | Final | W | 17 |
| 28 | 2026-02-23 | Louisville (21) | 74 | 77 | North Carolina (24) | Final | L | -3 |
| 29 | 2026-02-28 | Louisville (21) | 75 | 80 | Clemson (39) | Final | L | -5 |
| 30 | 2026-03-03 | Syracuse (74) | 62 | 77 | Louisville (25) | Final | W | 15 |
| 31 | 2026-03-07 | Louisville (25) | 92 | 89 | Miami (28) | Final | W | 3 |
| 32 | 2026-03-11 | SMU (42) | 58 | 62 | Louisville (22) | Final | W | 4 |
| 33 | 2026-03-12 | Louisville (22) | 73 | 78 | Miami (28) | Final | L | -5 |
| 34 | 2026-03-19 | South Florida (60) | 79 | 83 | Louisville (21) | Final | W | 4 |
| 35 | 2026-03-21 | Louisville (21) | 69 | 77 | Michigan State (9) | Final | L | -8 |