Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-11-03 | Lehigh (311) | 57 | 75 | Houston (4) | Final | W | 18 |
| 2 | 2025-11-08 | Towson (131) | 48 | 65 | Houston (4) | Final | W | 17 |
| 3 | 2025-11-12 | Oakland (189) | 45 | 78 | Houston (4) | Final | W | 33 |
| 4 | 2025-11-16 | Houston (4) | 73 | 72 | Auburn (2) | Final | W | 1 |
| 5 | 2025-11-20 | Rider (294) | 45 | 91 | Houston (4) | Final | W | 46 |
| 6 | 2025-11-24 | Syracuse (121) | 74 | 78 | Houston (4) | Final/OT | W | 4 |
| 7 | 2025-11-25 | Tennessee (5) | 76 | 73 | Houston (4) | Final | L | -3 |
| 8 | 2025-11-26 | Notre Dame (109) | 56 | 66 | Houston (4) | Final | W | 10 |
| 9 | 2025-12-06 | Florida State (75) | 67 | 82 | Houston (22) | Final | W | 15 |
| 10 | 2025-12-10 | Jackson State (327) | 38 | 80 | Houston (17) | Final | W | 42 |
| 11 | 2025-12-13 | New Orleans (305) | 57 | 99 | Houston (17) | Final | W | 42 |
| 12 | 2025-12-20 | Houston (14) | 94 | 85 | Arkansas (15) | Final | W | 9 |
| 13 | 2025-12-29 | Middle Tennessee (123) | 60 | 69 | Houston (13) | Final | W | 9 |
| 14 | 2026-01-03 | Houston (13) | 67 | 60 | Cincinnati (127) | Final | W | 7 |
| 15 | 2026-01-06 | Texas Tech (18) | 65 | 69 | Houston (14) | Final | W | 4 |
| 16 | 2026-01-10 | Houston (14) | 77 | 55 | Baylor (55) | Final | W | 22 |
| 17 | 2026-01-13 | West Virginia (74) | 48 | 77 | Houston (12) | Final | W | 29 |
| 18 | 2026-01-18 | Arizona State (73) | 73 | 103 | Houston (9) | Final | W | 30 |
| 19 | 2026-01-24 | Houston (9) | 86 | 90 | Texas Tech (14) | Final | L | -4 |
| 20 | 2026-01-28 | Houston (11) | 79 | 70 | TCU (42) | Final | W | 9 |
| 21 | 2026-01-31 | Cincinnati (81) | 54 | 76 | Houston (11) | Final | W | 22 |
| 22 | 2026-02-04 | Central Florida (19) | 55 | 79 | Houston (10) | Final | W | 24 |
| 23 | 2026-02-07 | Houston (10) | 77 | 66 | BYU (15) | Final | W | 11 |
| 24 | 2026-02-10 | Houston (6) | 66 | 52 | Utah (121) | Final | W | 14 |
| 25 | 2026-02-14 | Kansas State (84) | 64 | 78 | Houston (6) | Final | W | 14 |
| 26 | 2026-02-16 | Houston (5) | 67 | 70 | Iowa State (7) | Final | L | -3 |
| 27 | 2026-02-21 | Arizona (3) | 73 | 66 | Houston (5) | Final | L | -7 |
| 28 | 2026-02-23 | Houston (6) | 56 | 69 | Kansas (15) | Final | L | -13 |
| 29 | 2026-02-28 | Colorado (68) | 62 | 102 | Houston (6) | Final | W | 40 |
| 30 | 2026-03-04 | Baylor (55) | 64 | 77 | Houston (6) | Final | W | 13 |
| 31 | 2026-03-07 | Houston (6) | 82 | 75 | Oklahoma State (56) | Final | W | 7 |
| 32 | 2026-03-12 | BYU (26) | 66 | 73 | Houston (7) | Final | W | 7 |
| 33 | 2026-03-13 | Kansas (16) | 47 | 69 | Houston (7) | Final | W | 22 |
| 34 | 2026-03-14 | Houston (7) | 74 | 79 | Arizona (3) | Final | L | -5 |
| 35 | 2026-03-19 | Idaho (199) | 47 | 78 | Houston (4) | Final | W | 31 |
| 36 | 2026-03-21 | Texas A&M (40) | 57 | 88 | Houston (4) | Final | W | 31 |
| 37 | 2026-03-26 | Illinois (12) | 65 | 55 | Houston (4) | Final | L | -10 |