Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-11-04 | Texas (47) | 60 | 75 | Duke (3) | Final | W | 15 |
| 2 | 2025-11-08 | Western Carolina (340) | 54 | 95 | Duke (3) | Final | W | 41 |
| 3 | 2025-11-11 | Duke (3) | 114 | 59 | Army (274) | Final | W | 55 |
| 4 | 2025-11-14 | Indiana State (197) | 62 | 100 | Duke (3) | Final | W | 38 |
| 5 | 2025-11-18 | Kansas (28) | 66 | 78 | Duke (3) | Final | W | 12 |
| 6 | 2025-11-21 | Niagara (320) | 42 | 100 | Duke (3) | Final | W | 58 |
| 7 | 2025-11-23 | Howard (331) | 56 | 93 | Duke (3) | Final | W | 37 |
| 8 | 2025-11-27 | Duke (3) | 80 | 71 | Arkansas (31) | Final | W | 9 |
| 9 | 2025-12-02 | Florida (28) | 66 | 67 | Duke (2) | Final | W | 1 |
| 10 | 2025-12-06 | Duke (2) | 66 | 60 | Michigan State (6) | Final | W | 6 |
| 11 | 2025-12-16 | Lipscomb (119) | 73 | 97 | Duke (2) | Final | W | 24 |
| 12 | 2025-12-20 | Texas Tech (29) | 82 | 81 | Duke (2) | Final | L | -1 |
| 13 | 2025-12-31 | Georgia Tech (137) | 79 | 85 | Duke (7) | Final | W | 6 |
| 14 | 2026-01-03 | Duke (7) | 91 | 87 | Florida State (132) | Final | W | 4 |
| 15 | 2026-01-06 | Duke (9) | 84 | 73 | Louisville (28) | Final | W | 11 |
| 16 | 2026-01-10 | SMU (17) | 75 | 82 | Duke (9) | Final | W | 7 |
| 17 | 2026-01-14 | Duke (8) | 71 | 56 | California (63) | Final | W | 15 |
| 18 | 2026-01-17 | Duke (8) | 80 | 50 | Stanford (49) | Final | W | 30 |
| 19 | 2026-01-24 | Wake Forest (60) | 69 | 90 | Duke (4) | Final | W | 21 |
| 20 | 2026-01-26 | Louisville (22) | 52 | 83 | Duke (3) | Final | W | 31 |
| 21 | 2026-01-31 | Duke (3) | 72 | 58 | Virginia Tech (47) | Final | W | 14 |
| 22 | 2026-02-03 | Boston College (154) | 49 | 67 | Duke (3) | Final | W | 18 |
| 23 | 2026-02-07 | Duke (3) | 68 | 71 | North Carolina (24) | Final | L | -3 |
| 24 | 2026-02-10 | Duke (3) | 70 | 54 | Pittsburgh (125) | Final | W | 16 |
| 25 | 2026-02-14 | Clemson (29) | 54 | 67 | Duke (3) | Final | W | 13 |
| 26 | 2026-02-16 | Syracuse (64) | 64 | 101 | Duke (2) | Final | W | 37 |
| 27 | 2026-02-21 | Michigan (1) | 63 | 68 | Duke (2) | Final | W | 5 |
| 28 | 2026-02-24 | Duke (2) | 100 | 56 | Notre Dame (95) | Final | W | 44 |
| 29 | 2026-02-28 | Virginia (13) | 51 | 77 | Duke (2) | Final | W | 26 |
| 30 | 2026-03-02 | Duke (2) | 93 | 64 | North Carolina State (38) | Final | W | 29 |
| 31 | 2026-03-07 | North Carolina (19) | 61 | 76 | Duke (2) | Final | W | 15 |
| 32 | 2026-03-12 | Florida State (66) | 79 | 80 | Duke (2) | Final | W | 1 |
| 33 | 2026-03-13 | Clemson (36) | 61 | 73 | Duke (2) | Final | W | 12 |
| 34 | 2026-03-14 | Virginia (12) | 70 | 74 | Duke (2) | Final | W | 4 |
| 35 | 2026-03-19 | Siena (169) | 65 | 71 | Duke (2) | Final | W | 6 |
| 36 | 2026-03-21 | TCU (28) | 58 | 81 | Duke (2) | Final | W | 23 |
| 37 | 2026-03-27 | St. John's (13) | 75 | 80 | Duke (2) | Final | W | 5 |
| 38 | 2026-03-29 | Connecticut (8) | 73 | 72 | Duke (2) | Final | L | -1 |