Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-11-03 | Chicago State (359) | 62 | 92 | DePaul (128) | Final | W | 30 |
| 2 | 2025-11-07 | Stonehill (310) | 64 | 72 | DePaul (128) | Final | W | 8 |
| 3 | 2025-11-11 | Buffalo (330) | 66 | 53 | DePaul (128) | Final | L | -13 |
| 4 | 2025-11-14 | Northwestern (57) | 81 | 79 | DePaul (128) | Final | L | -2 |
| 5 | 2025-11-18 | Gardner-Webb (269) | 62 | 93 | DePaul (128) | Final | W | 31 |
| 6 | 2025-11-23 | Detroit (328) | 75 | 95 | DePaul (128) | Final | W | 20 |
| 7 | 2025-11-28 | Georgia Tech (103) | 61 | 75 | DePaul (128) | Final | W | 14 |
| 8 | 2025-11-29 | DePaul (128) | 63 | 96 | LSU (78) | Final | L | -33 |
| 9 | 2025-12-06 | Arkansas-Pine Bluff (344) | 72 | 76 | DePaul (154) | Final | W | 4 |
| 10 | 2025-12-09 | Morgan State (360) | 49 | 92 | DePaul (164) | Final | W | 43 |
| 11 | 2025-12-13 | DePaul (164) | 61 | 58 | Wichita State (113) | Final | W | 3 |
| 12 | 2025-12-16 | DePaul (128) | 66 | 79 | St. John's (38) | Final | L | -13 |
| 13 | 2025-12-21 | Connecticut (5) | 72 | 54 | DePaul (135) | Final | L | -18 |
| 14 | 2025-12-31 | DePaul (140) | 66 | 71 | Villanova (16) | Final | L | -5 |
| 15 | 2026-01-03 | Xavier (87) | 77 | 86 | DePaul (140) | Final | W | 9 |
| 16 | 2026-01-06 | Georgetown (109) | 50 | 56 | DePaul (112) | Final | W | 6 |
| 17 | 2026-01-10 | DePaul (112) | 60 | 72 | Connecticut (8) | Final | L | -12 |
| 18 | 2026-01-16 | Marquette (165) | 75 | 80 | DePaul (103) | Final | W | 5 |
| 19 | 2026-01-20 | DePaul (96) | 80 | 87 | Butler (58) | Final | L | -7 |
| 20 | 2026-01-24 | Seton Hall (42) | 60 | 67 | DePaul (96) | Final | W | 7 |
| 21 | 2026-01-28 | DePaul (88) | 61 | 70 | Georgetown (108) | Final | L | -9 |
| 22 | 2026-01-31 | DePaul (88) | 66 | 68 | Xavier (84) | Final | L | -2 |
| 23 | 2026-02-03 | St. John's (26) | 68 | 56 | DePaul (96) | Final | L | -12 |
| 24 | 2026-02-07 | DePaul (96) | 72 | 90 | Providence (97) | Final | L | -18 |
| 25 | 2026-02-11 | Creighton (69) | 71 | 72 | DePaul (104) | Final | W | 1 |
| 26 | 2026-02-18 | DePaul (98) | 69 | 57 | Seton Hall (49) | Final | W | 12 |
| 27 | 2026-02-21 | Providence (87) | 71 | 68 | DePaul (98) | Final | L | -3 |
| 28 | 2026-02-25 | DePaul (96) | 72 | 71 | Creighton (77) | Final | W | 1 |
| 29 | 2026-03-01 | DePaul (88) | 62 | 51 | Marquette (123) | Final | W | 11 |
| 30 | 2026-03-04 | Villanova (26) | 76 | 57 | DePaul (88) | Final | L | -19 |
| 31 | 2026-03-07 | Butler (77) | 81 | 71 | DePaul (88) | Final | L | -10 |
| 32 | 2026-03-11 | Georgetown (95) | 63 | 56 | DePaul (93) | Final | L | -7 |